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A: Tramadol (Ultram) is a centrally acting analgesic with a unique, dual mechanism of action. It works as an opioid and also has weak inhibitory effects on the brain chemicals norepinephrine and serotonin. Withdrawal symptoms may include anxiety, sweating, nausea, tremors, diarrhea, upper respiratory symptoms, insomnia, pain, tingling, and rarely hallucinations. These symptoms can be worse in patients who have been previously dependent or chronically taking other opioid drugs (such as Vicodin). Experience suggests that withdrawal symptoms may be relieved by tapering the dosage of tramadol. The slower the tapering, the fewer withdrawal symptoms would be expected. With respect to the side effects you describe in your question, according to the package insert for tramadol, headache was reported in 18 percent and 32 percent of patients treated with immediate-release tramadol for seven and 90 days, respectively. Overuse of analgesics such as tramadol products by headache-prone patients frequently produces drug-induced rebound headache. In this case, overuse of tramadol products has been defined as taking three or more doses per day more often than three to five days per week. There is no information to suggest that tramadol can cause changes to the menstrual cycle. For more information, please consult with your health care provider and visit //www.everydayhealth.com/drugs/tramadol. Michelle McDermott, PharmD
However, serotonin syndrome is more likely to occur when Ultram is concomitantly administered with other serotonergic medications, such as SSRIs, TCAs, MAOIs, serotonin norepinephrine reuptake inhibitors (SNRIs), the triptans (medications used in the treatment of migraine headaches), linezolid, lithium or St. John’s Wort. Serotonin syndrome is a potentially life-threatening medical condition, which can lead to death if left untreated. Serotonin syndrome, related to Ultram treatment, occurred in less than one percent of patients during clinical studies and/or post marketing experience.
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A: Tramadol (Ultram) is a centrally acting analgesic with a unique, dual mechanism of action. It works as an opioid and also has weak inhibitory effects on the brain chemicals norepinephrine and serotonin. Withdrawal symptoms may include anxiety, sweating, nausea, tremors, diarrhea, upper respiratory symptoms, insomnia, pain, tingling, and rarely hallucinations. These symptoms can be worse in patients who have been previously dependent or chronically taking other opioid drugs (such as Vicodin). Experience suggests that withdrawal symptoms may be relieved by tapering the dosage of tramadol. The slower the tapering, the fewer withdrawal symptoms would be expected. With respect to the side effects you describe in your question, according to the package insert for tramadol, headache was reported in 18 percent and 32 percent of patients treated with immediate-release tramadol for seven and 90 days, respectively. Overuse of analgesics such as tramadol products by headache-prone patients frequently produces drug-induced rebound headache. In this case, overuse of tramadol products has been defined as taking three or more doses per day more often than three to five days per week. There is no information to suggest that tramadol can cause changes to the menstrual cycle. For more information, please consult with your health care provider and visit //www.everydayhealth.com/drugs/tramadol. Michelle McDermott, PharmD
However, serotonin syndrome is more likely to occur when Ultram is concomitantly administered with other serotonergic medications, such as SSRIs, TCAs, MAOIs, serotonin norepinephrine reuptake inhibitors (SNRIs), the triptans (medications used in the treatment of migraine headaches), linezolid, lithium or St. John’s Wort. Serotonin syndrome is a potentially life-threatening medical condition, which can lead to death if left untreated. Serotonin syndrome, related to Ultram treatment, occurred in less than one percent of patients during clinical studies and/or post marketing experience.
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