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VIAGRA usually starts to work within 30-60 minutes. You may take it up to 4 hours before sexual activity. So there’s no need to rush. You may take it as much as four hours before sexual activity. You should not take Viagra more than once a day. Viagra should be taken an hour or so before anticipated sexual activity. Other drugs for erectile dysfunction include Cialis, which should be taken within half an hour.
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viagra is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes. The major product of metabolisation by these enzymes is N-desmethylated viagra, which is metabolised further. This metabolite also has an affinity for the PDE receptors, about 40% of that of viagra. Thus, the metabolite is responsible for about 20% of viagra’s action. viagra is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose). If taken with a high-fat meal, absorption is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third.[34]
VIAGRA usually starts to work within 30-60 minutes. You may take it up to 4 hours before sexual activity. So there’s no need to rush. You may take it as much as four hours before sexual activity. You should not take Viagra more than once a day. Viagra should be taken an hour or so before anticipated sexual activity. Other drugs for erectile dysfunction include Cialis, which should be taken within half an hour.
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