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Q: How long does it take for tramadol to leave your system? A: The amount of time it takes to eliminate a drug from the body will depend on the half-life of the medication. The half-life is the amount of time it takes for half the amount of drug to be cleared from the body. Therefore, after one half-life, half of the drug has left in the body. It takes approximately five half-lives to eliminated most of a drug from the body. The half-life of tramadol (Ultram) is about seven hours. Therefore, it can take up to 35 hours to completely eliminate tramadol.
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