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Q: Does tramadol show up in rapid strip drug screens? A: Ultram (tramadol) is a medication used to manage pain, and although there are specific tests developed to detect the medication, the chance if it showing up on a rapid strip drug screen depends on which version is being used by the facility. The most basic version will not show Ultram (tramadol) as an opiate. It is not a typical opiate, but it does bind to the opiate receptors in the CNS (central nervous system) to block the pain signal. It also blocks the reuptake of norepinephrine and serotonin, which can further help to block the pain signal from reaching the brain. The medication was developed as an answer to the older, traditional, but addictive opiates, but the metabolite (what the medication breaks down into) has been found to also cause some addiction as well.
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