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Drug interactions. Avoid taking certain medications that can affect the removal of eletriptan from your body within 72 hours of taking eletriptan. Examples include cobicistat, nefazodone, azole antifungals such as ketoconazole/itraconazole, macrolide antibiotics such as clarithromycin/erythromycin, certain hepatitis C virus protease inhibitors such as boceprevir/telaprevir, HIV protease inhibitors such as nelfinavir/ritonavir, among others. If you also take any ergotamine medication (such as dihydroergotamine) or other “triptan” drugs (such as sumatriptan, rizatriptan), separate your eletriptan dose at least 24 hours apart from your dose of these other medications to lessen the chance of serious side effects. The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/”ecstasy,” St. John’s wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.
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