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Table 1 displays three ranges of expected maintenance COUMADIN doses observed in subgroups of coumadin patients having different combinations of CYP2C9 and VKORC1 gene variants [see CLINICAL PHARMACOLOGY] . Patients with CYP2C9 *1/*3, *2/*2, *2/*3, and *3/*3 may require more prolonged time ( > 2 to 4 weeks) to achieve maximum INR effect for a given dosage regimen than patients without coumadin trade name pt range on coumadin inr levels on coumadin coumadin mg tablets coumadin these CYP variants . If the coumadin patient’s CYP2C9 and/or VKORC1 genotype are known, consider these ranges in choosing the initial dose .
COUMADIN may increase coumadin the activated partial thromboplastin time (aPTT) test, even in the absence of heparin . A severe elevation ( > 50 seconds) coumadin in aPTT with an INR in the desired range has been identified as an indication of increased risk of postoperative hemorrhage .

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